Day 1 :
- Pathology
Location: Online
Session Introduction
Dr. Chaya Prasad
Director, Center for Autism and Intellectual Developmental Disorders
Title: Female adnexal tumour of probable Wolfï¬an origin arising from ovary: A case report and review of literature.
Biography:
Dr. Chaya Prasad, MD is a Anatomic & Clinical Pathology Specialist in Pomona, CA.
Abstract:
Female adnexal tumors of probable Wolfï¬an origin (FATWO) are rare and present a diagnostic challenge due to their morphological and immunohistochemical overlap. It was ï¬rst described in 1973 by Kariminejad and Scully as it’s a single tumour. It originates from mesonephric remnants, occurring in the broad ligament, mesosalpinx, fallopian tube, ovary and peritoneum. The clinical behaviour of FATWO is generally benign, but malignant cases do exist. Less than 90 cases having been reported worldwide. Here we present a rare case of FATWO arising from ovary and review the literature based on the pathological and immunohistochemical results.
Shinya Tajima
Department of Pathology, St. Marianna University School of Medicine, Kawasaki city, Kanagawa prefecture, Japan
Title: Intraductal nuclear inverse-polarity papillary lesions without bilayer structure: a report of two cases
Biography:
I am Shinya Tajima MD, PhD from Japan. I was born in 1976 in Saitama near Tokyo. I graduated from Keio University School of Medicine. After graduated the university, working in Department of Pathology at the same institution. I received PhD in Radiologic-Pathology from St. Marianna University Graduate School of Medicine, Kanagawa, Japan. I am currently working at the Department of Pathology and Radiology of this latter institution. My interests are breast pathology, breast radiology and breast radio-pathological correlation.
Abstract:
Previous reports have described the occurrence of apocrine lesions lacking myoepithelial cells however benign. Here, we report 2 cases of “non-apocrine” papillary lesions lacking myoepithelial cells associated with interesting immunohistochemistry results and clinico-pathological features. In our cases, histologically both papillary lesions were lined by a fibrovascular core and nuclear inverse-polarity without nuclear atypia. Loss of myoepithelial cells was observed by H&E, p63 and Calponin stainings. Some reports have indicated that cytokeratin (CK)5/6 and estrogen receptor (ER) immunostainings are important for differentiating benign versus malignant lesions. Moreover, previous report indicate p63 and MUC3 are important for distinguishing between papillary lesions according to the differential index (based on the Allred score) of ([ER total score] + [MUC3 total score])/([CK5/6 total score] + [p63 total score] + 1). Based on this analysis, our 2 cases had benign lesions