2nd Webinar on Pathology
London, UK
Shinya Tajima
Department of Pathology, St. Marianna University School of Medicine, Kawasaki city, Kanagawa prefecture, Japan
Title: Intraductal nuclear inverse-polarity papillary lesions without bilayer structure: a report of two cases
Biography
Biography: Shinya Tajima
Abstract
Previous reports have described the occurrence of apocrine lesions lacking myoepithelial cells however benign. Here, we report 2 cases of “non-apocrine” papillary lesions lacking myoepithelial cells associated with interesting immunohistochemistry results and clinico-pathological features. In our cases, histologically both papillary lesions were lined by a fibrovascular core and nuclear inverse-polarity without nuclear atypia. Loss of myoepithelial cells was observed by H&E, p63 and Calponin stainings. Some reports have indicated that cytokeratin (CK)5/6 and estrogen receptor (ER) immunostainings are important for differentiating benign versus malignant lesions. Moreover, previous report indicate p63 and MUC3 are important for distinguishing between papillary lesions according to the differential index (based on the Allred score) of ([ER total score] + [MUC3 total score])/([CK5/6 total score] + [p63 total score] + 1). Based on this analysis, our 2 cases had benign lesions